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Falls can pose a serious health threat, especially for older people, often leading to fractures, head injuries, or long-term disability. This highlights the need for reliable and non-invasive detection systems. Existing solutions often suffer from limitations such as user discomfort with wearables, constrained coverage of fixed sensors, or environmental challenges in vision-based methods. This paper proposes a dual-stream attention-guided robust indoor fall detection framework to solve the problem. The approach combines a pose-guided stream with a video stream, in which the former captures high-level skeletal features through MediaPipe and simultaneously processes spatiotemporal dynamics from raw RGB frames using a 3D Convolutional Neural Network (CNN) with a temporal attention module. In order to enhance classification precision, features from each stream are adaptively fused in a block based on attention mechanisms, which improves the model’s interpretation of posture and movement semantics. Testing on the KFall dataset reveals that the proposed method achieves 98.71% accuracy, surpassing pre-existing benchmarks. Triggering a visual alert by displaying a red rectangle on the screen upon the occurrence of this event is a subsequent outcome of this work. An ablation study highlights the effectiveness of each component. Finally, the proposed work advances fall detection by combining pose estimation and attention-based deep learning to deliver an accurate, interpretable, and deployable solution.

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Mucosal-mediated immune deficiency is associated with immune evasion and poor clinical outcomes in acute myeloid leukemia (AML). Here, we describe the elicitation of mucosal and systemic immune response by oral delivery of MDP-modified PEG-lipid (MDP-PEG-DSPE) and polylactic acid–polyhistidine (PLA–PHis) copolymer constructed nanosystem (mPOD) into Peyer’s patches. To protect against gastrointestinal degradation, enteric-soluble capsules are utilized for encapsulating mPOD to promote penetration across intestinal mucus and engender robust Peyer’s patch targeting initiated by MDP-PEG-DSPE. Compared with intravenous and intramuscular administration, the oral delivery of MDP-PEG-DSPE and 5′-triphosphate-modified RNA (ppp-RNA) into gut-associated lymphoid tissues reinforces dendritic cell maturation and migration, amplifies mucosal immune response, and boosts the production of secretory immunoglobulin A via retinoic acid-inducible gene I/nucleotide-binding oligomerization domain 2 (RIG-I/NOD2) signaling activation. In the AML murine model, the provoked mucosal immunity positively regulates the systemic cytotoxic immune reactions, which, in turn, eradicate disseminated malignant leukemic cells and provide defense against leukemia attacks.

The Catch can now be found in Standing by the Wall, the collection of other novellas set in the world of the New York Times bestselling Slough House series.John Bachelor is the saddest kind of spy: not a joe in the field, not even a desk jockey, but a milkman—a part-time pension administrator whose main job is to check in on aging retired spies. Late in his career and having lost his wife, his house, and his savings after a series of unlucky choices, John's been living in a dead man's London apartment, hoping the bureaucracy isn't going to catch up with him and leave him homeless. But keeping a secret among spies is a fool's errand, and now John has made himself eminently blackmailable.

The notion of green industrial policy (GIP) has gained attention recently in order to conceptualize the relationship between the transition to green technologies and the development of domestic manufacturers of such technologies. In this paper, we contribute to advancing the literature on GIP by presenting a conceptual framework on GIP in the context of latecomer catch-up of domestic firms in developing countries. The framework combines insights from the development studies literature on industrial policies, policy mixes in sustainability transition studies and the literature on firm-level catch-up. We apply the framework to study how industrial policies and energy policies have interacted and influenced the initial entry and early-stage catch-up of domestic solar PV module manufacturers in Indonesia in the period 2008–2023. Empirically, we draw on semi-structured interviews with representatives of domestic solar PV module manufacturers, industry informants and relevant government agencies. Based on the conceptual framework, we identify the inhibiting and encouraging factors influencing firm-level catch-up trajectories within three distinctive phases. We find that, while the catch-up trajectory of domestic solar PV module manufacturers resembled a path toward coexistence during the first and second phases, the third phase involved an aborted catch-up trajectory. However, a new catch-up trajectory toward coexistence may be emerging in relation to the recent establishment of export-oriented solar PV module production. Conceptually, the paper contributes to advancing the literature on GIPs by adopting a firm-oriented perspective and by seeking closer integration with research in development studies on the catching-up of latecomer firms.

The aim of the study was to assess the cost-effectiveness of a catch-up vaccination against HPV of unvaccinated adolescent boys and young men in Sweden. Costs and health effects of HPV related cancer in such situation was compared to no vaccination of the same cohort.We used a dynamic Markov multi-state model to simulate the burden of HPV related cancer in Sweden and the effects of a catch-up vaccination in adolescent boys and young men compared to no vaccination. The model accounted for direct effects of preventing cancer in vaccinated individuals and indirect effects of vaccination through herd-immunity. The main epidemilogical outcome was the number of HPV related cancers in men and women. Costs included resource use for HPV related cancer, production loss when sick, and the cost of the vaccine and administration. Health effects were measured as quality-adjusted life years (QALY). Costs and QALYs were accumulated over the simulated time-horizon to calculate the cost per gained QALY.A HPV catch-up vaccination strategy for adolescents boys and young men would lead to a reduction in the number of HPV related cancers, both through direct and indirect effects. Vaccinating a birth cohort of boys aged 17–19 would lead to a reduction of about 510 cases of HPV related cancer over the simulated time-horizon. The corresponding figures for ages 17–26 and 17–30 were 1450 and 2080 respectively. The cost per gained QALY was EUR 50,100 for 17–19, EUR 42,800 for 17–26, and EUR 32,800 for 17–30 years old.Providing catch up vaccination to adolescent boys and young men aged 17–26 years old can be considered good value for money in a Swedish setting. The results are sensitive to changes in the vaccine effectiveness, which is greater before being exposed to the virus, and to the price of the vaccine.