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Why does my library account say that I am blocked, that I am barred, or that my status is expired?
Users can encounter several different types of status messages. Patrons with questions about their account status can visit the checkout desk in room 241 of LSU Library and ask to speak to a staff member. Alternatively, patrons can reach out to us via e-mail at libcirc@lsu.edu (mailto:libcirc@lsu.edu) . When contacting us via e-mail, LSU students, staff, and faculty should message us from their LSU e-mail address; public patrons should message us from the e-mail address we have on file. For privacy reasons, we cannot discuss the details of patron accounts over the telephone. Expired: Students must be currently enrolled in classes in order to be granted library privileges. Once they graduate, or if they fail to register on time in accord with the deadlines posted on LSUs academic calendar, their privileges expire. If they try to log in to their library account after that date, they will see an alert message informing them that their account has expired. Graduate students who have received a masters degree but are continuing on to get their PhD may also have their privileges expire earlier than expected. The library receives weekly updates on student status from the Registrars Office. Once the semester has begun, if students register during the week, their accounts will not be updated and their privileges extended in the system until the following Monday morning. Blocked: Users with overdue recalled books will have their accounts blocked by the system. Their accounts will remain blocked until the book is returned. The system will not permit staff members to override blocks or to renew books that have been recalled. The only way to remove a block from an account is to return the materials. Barred: Users can be barred from using library materials for a number of reasons, the most common being that they have been billed for lost items. They can also be barred if they resign from the university, if their classes are purged, or for flagrant violations of library policy. If they try to log into their account after they have been barred, they will receive an alert message that tells them that they have been barred. Answered by: Access Services Staff

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2064992
The C-terminal actin-binding domain of talin forms an asymmetric catch bond with F-actin
Focal adhesions (FAs) are large, integrin-based protein complexes that link cells to the extracellular matrix (ECM). FAs form only when and where they are necessary to transmit force between the cellular cytoskeleton and the ECM, but how this occurs remains poorly understood. Talin is a 270-kDa adaptor protein that links integrins to filamentous (F)-actin and recruits additional components during FA assembly in a force-dependent manner. Cell biological and developmental data demonstrate that the third and C-terminal F-actin–binding site (ABS3) of talin is required for normal FA formation. However, purified ABS3 binds F-actin only weakly in solution. We used a single molecule optical trap assay to examine how and whether ABS3 binds F-actin under physiologically relevant mechanical loads. We find that ABS3 forms a catch bond with F-actin when force is applied toward the pointed end of the actin filament, with binding lifetimes >100-fold longer than when force is applied toward the barbed end. Long-lived bonds to F-actin under load require the ABS3 C-terminal dimerization domain, whose cleavage has been reported to regulate FA turnover. Our results support a mechanism in which talin ABS3 preferentially binds to and orients actin filaments with barbed ends facing the cell periphery, thus nucleating long-range order in the actin cytoskeleton. We suggest that talin ABS3 may function as a molecular AND gate that allows FA growth only when sufficient integrin density, F-actin polarization, and mechanical tension are simultaneously present.