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The study aimed to investigate the long-term effects of IUGR and consequent catch-up growth on metabolic health by using a comprehensive approach that included histopathological, immunohistochemical, biochemical, and metabolomics analyses. Sprague–Dawley pregnant rats either undergo bilateral uterine artery ligation or a sham surgery on the 19th day of gestation. The offspring reached catch-up growth, kidney samples were collected at postnatal weeks 2, 4, and 8 for analysis. IUGR rats exhibited a spectrum of changes including reduced glomeruli number, proliferating cell number, altered oxidative stress markers, various enzymes involved in Krebs cycle, mitochondrial dynamics, and energy metabolism. Examination of the 8-week-old cohort identified a broader spectrum of metabolic alterations, notably in the biosynthesis of phenylalanine, tyrosine, and tryptophan, phenylalanine, tyrosine, glyoxylate, dicarboxylate, pyruvate, alanine, aspartate, and glutamate metabolism, glycolysis/gluconeogenesis and citrate (TCA) cycle. Our metabolomics analysis provides insights into the potential disease susceptibility of individuals born with IUGR, including obesity, diabetes, hypertriglyceridemia, cardiovascular diseases, and mental retardation. These findings underscore the intricate interplay between intrauterine conditions and long-term metabolic health outcomes, highlighting the need for further investigation into preventive and therapeutic strategies to mitigate the risk of metabolic diseases in individuals with a history of IUGR.

This paper addresses the challenge of missing data in scientific research. It specifically examines the case of missing data arising from a “catch-all” missing not at ran (MNAR) mechanism, where missing values are disproportionately from one category, such as income or ethnicity in surveys. The study introduces the use of the regression diagnostic DFBETAS along with Leverage to improve the imputation of categorical data under such conditions. DFBETAS, a measure of influence in regression, is adapted to capture the intrinsic information of missing values, thereby enhancing the imputation process within a Bayesian multiple imputation (MI) framework. We validate the proposed approach through Monte Carlo simulations with data generating mechanisms based on probability distributions. The results show that incorporating DFBETAS and Leverage significantly improves the accuracy of imputations, optimizes the balance between its sensitivity and specificity reduces bias, and enhances confidence interval coverage of imputed estimates, especially as the strength of the catch-all mechanism increases. The study demonstrates that MI with DFBETAS and Leverage outperforms standard MI methods, offering a robust solution for handling categorical data with catch-all MNAR mechanisms. This advancement in imputation methodology provides a more accurate and efficient means of dealing with missing data in various research fields.

Our aim in this study was to analyze associations between the two manipulative tests of the Motor Competence Assessment (MCA) battery and the Wall Drop Punt Kick & Catch (WDPK&C) motor task. One hundred and twelve early adolescents (60 boys; 52 girls; M age = 12.67, SD = 1.78 years) participated. Overall, strong correlations were found between the WDPK&C and the MCA manipulative tests, either separately (r = 0.802 for kicking, r = 0.762 for throwing) or collectively (r = 0.835). In boys, correlations between WDPK&C and MCA kicking (r = 0.722) and MCA throwing (r = 0.754) were similar. In girls, MCA kicking was more closely related to WDPK&C performance (r = 0.612) than MCA throwing (r = 0.330). These results reinforce the possible use of WDPK&C as a gross manipulative coordination test, either by itself or when integrated into motor competence batteries.

This study examined the impact of Catch-Up Sleep Ratio (CSR) on health outcomes in Korean adults. Adjusted for age and gender, 2,484 participants were categorized into three groups: Weekday (CSR

FBI agents are trained to delve deep into the minds of the most dangerous predators. So when the tables are turned and the hunter becomes the prey, they can trust their instincts—and their hearts—to keep each other from harm... FBI Special Agent Hannah Cambridge is trying to rebuild her life after the death of her partner. But Jack Benton wasn't just a fellow agent. He was her lover—and the father of her newborn baby. Now Hannah is in Boston, heading a task force to catch a serial killer. It's a case that could make or break her career. Until the madman turns his twisted sights on her... When Jack Benton went deep undercover, he thought it was a way out of a relationship that was spiraling beyond his control. He never knew Hannah wouldn't be told about his “death”—or that she was pregnant. Turning up in Boston in the flesh, and looking better than ever, will send Hannah into a tailspin. But both will need to keep their wits about them to keep her alive—and to survive the truth about the passion that binds them...

Army deserter Abel de Santiago has all but avenged his murdered wife, when he is captured and sold as a galley slave. As the Spanish Armada sails for Calais Roads in May 1588, there cannot be a soul aboard more reluctant than him.After a crushing defeat to the English fleet, the Spanish ships are battered by extraordinary storms. Santiago soon finds himself washed ashore in Ireland, a country terrorised by men that the natives call Sassenachs.Santiago's faint hopes of survival appear dashed when he is captured by the brutal Sheriff of Sligo, who has orders from Dublin to torture and kill all Spanish castaways. An unlikely twist of fate leaves Santiago fleeing Sligo with a jewelled ring worth a King's ransom. His escape leads to a desperate chase across a strange and stunning land, where danger lurks at every turn.So begins THE SHERIFF'S CATCH, being Part 1 of THE SASSANA STONE PENTALOGY