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Background: Depression is a prevalent disorder with significant health impacts. Physical activity is known to protect against depression, but its effects may vary in populations with disrupted sleep patterns, such as weekend catch-up sleepers, which refers to participants who sleep longer on weekends than on weekdays. This study examines the dose-response relationship between physical activity and depression in this population. Methods: Data from 1,906 participants in the National Health and Nutrition Examination Survey (2021–2023) were analyzed. Physical activity was measured in MET-minutes per week, and depression was assessed using the PHQ-9. Multivariate linear regression, restricted cubic spline, and two-part linear regression models were employed. Results: In the adjusted model, physical activity showed a negative trend with depression, though this association did not reach statistical significance in the fully adjusted model. Stratified analyses revealed stronger associations in women (OR = 0.86, 95% CI: 0.75, 0.99, P = 0.0329) and individuals aged 40–60 years (OR = 0.79, 95% CI: 0.65, 0.97, P = 0.0237). A threshold effect was observed, with physical activity below 2.48 MET-min/1000-wk showing a negative association with depression (OR = 0.69, 95% CI: 0.56, 0.85, P = 0.0006). Beyond this threshold, the relationship changed. Conclusion: A nonlinear relationship between physical activity and depression was identified in weekend catch-up sleepers, with moderate activity levels (2.48 MET-min/1000-wk) offering the greatest mental health benefits, particularly in women and individuals aged 40–60 years. Clinical trial number: Not applicable. [ABSTRACT FROM AUTHOR]

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Despite the breakthrough achievements in understanding structural and functional alterations of brain connectivity in autism spectrum disorder (ASD), the exact nature and type of such alterations are not yet clear due to conflicting reports of hyper-connectivity, hypo-connectivity, and—in some cases—combinations of both. In this work, we bring order to the debate using a network comparison technique to capture mesoscopic-scale differential patterns of functional connectedness. In particular, we leverage recent algorithmic advances in extracting contrast subgraphs to identify maximally different mesoscopic connectivity structures between two sets of networks from typically developed individuals and ASD subjects across different developmental stages. A significantly larger connectivity among occipital cortex regions and between the left precuneus and the superior parietal gyrus was found in ASD subjects. At the same time, reduced connectivity characterized the superior frontal gyrus and the temporal lobe regions. More importantly, our results reconcile within a single framework multiple previous separate observations about functional connectivity alterations in ASD.

Recently, China has undergone rapid urbanization in terms of population and urban land growth. However, there are notable lags in the people-oriented dimensions of urbanization, including urban social services, environmental services, and socioeconomic equity, which are crucial for achieving SDG11 (sustainable cities and communities). Here, considering the complex dimensions of urbanization, we examined 16 people-oriented urbanization indicators across four dimensions, namely, economic, social, environmental, and equity dimensions, from 2005 to 2020, and their relationships with population/land urbanization at multiple scales (national, regional, and urban agglomeration scales), and among different city sizes, via the paired t test and the evenness index. Notably, between 2005 and 2020, these urbanization indicators of China showed an overall upward trend, with changes ranging from 1.09 to 53.95 times. Among the 16 people-oriented urbanization indicators, the economic and social indicators lagged behind the land and population urbanization, whereas the environmental indicators caught up. The evenness index among these indicators showed a U-shaped change pattern, which indicated that people-oriented urbanization was coming up with population/land urbanization since the implementation of China new-type urbanization plan in 2014 until 2020. In the future, increasing investment in social service systems and implementing place-based coordination strategies are necessary to make cities inclusive, safe, resilient, and sustainable.