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Despite the breakthrough achievements in understanding structural and functional alterations of brain connectivity in autism spectrum disorder (ASD), the exact nature and type of such alterations are not yet clear due to conflicting reports of hyper-connectivity, hypo-connectivity, and—in some cases—combinations of both. In this work, we bring order to the debate using a network comparison technique to capture mesoscopic-scale differential patterns of functional connectedness. In particular, we leverage recent algorithmic advances in extracting contrast subgraphs to identify maximally different mesoscopic connectivity structures between two sets of networks from typically developed individuals and ASD subjects across different developmental stages. A significantly larger connectivity among occipital cortex regions and between the left precuneus and the superior parietal gyrus was found in ASD subjects. At the same time, reduced connectivity characterized the superior frontal gyrus and the temporal lobe regions. More importantly, our results reconcile within a single framework multiple previous separate observations about functional connectivity alterations in ASD.

Recently, China has undergone rapid urbanization in terms of population and urban land growth. However, there are notable lags in the people-oriented dimensions of urbanization, including urban social services, environmental services, and socioeconomic equity, which are crucial for achieving SDG11 (sustainable cities and communities). Here, considering the complex dimensions of urbanization, we examined 16 people-oriented urbanization indicators across four dimensions, namely, economic, social, environmental, and equity dimensions, from 2005 to 2020, and their relationships with population/land urbanization at multiple scales (national, regional, and urban agglomeration scales), and among different city sizes, via the paired t test and the evenness index. Notably, between 2005 and 2020, these urbanization indicators of China showed an overall upward trend, with changes ranging from 1.09 to 53.95 times. Among the 16 people-oriented urbanization indicators, the economic and social indicators lagged behind the land and population urbanization, whereas the environmental indicators caught up. The evenness index among these indicators showed a U-shaped change pattern, which indicated that people-oriented urbanization was coming up with population/land urbanization since the implementation of China new-type urbanization plan in 2014 until 2020. In the future, increasing investment in social service systems and implementing place-based coordination strategies are necessary to make cities inclusive, safe, resilient, and sustainable.

To compare the difference between appropriate for gestational age (AGA) and small for gestational age (SGA) of singleton and twin in terms of catch-up growth (CUG) and nutritional status in the first year after birth through a prospective cohort study. A total of 340 singleton and twin children were recruited. Dietary questionnaires were completed at enrollment and at 3 and 6 months of age. Anthropometric data were presented as Z scores. The Z score of weight, length and/or head circumference > − 2SD were used as criteria for CUG. The CUG rate of the twin AGA was the highest. Rapid CUG of twin SGA occurred within 3 months, and the CUG rate of weight was greater for twin SGA than for singleton SGA at 1 year old. The length CUG rate for twin SGA was the lowest within 3 months, 17.05% of the singleton SGA and 22.22% of the twin SGA did not reach CUG. The CUG was independent of feeding mode, and higher energy support did not improve CUG outcome. Twin AGA children have a better CUG rate, whereas CUG might take longer in SGA, especially for twin SGA. Higher energy support does not necessarily improve CUG outcomes. Trial registration number The study was registered in the Chinese Clinical Trial Registry with registration number ChiCTR2100053434 and was recorded in the medical research registry. Date of registration: Nov 21, 2021 [ABSTRACT FROM AUTHOR]

We study how housing market conditions shape the housing careers of Australians. Utilising data from the Australian Census spanning from 1991 to 2021, we observe significant differences in ownership rates at age 30 across birth cohorts. Moreover, these differences widen significantly as housing affordability falls. Using synthetic cohort techniques, we evaluate the persistence of these differences. Our results reveal that while the homeownership rates of younger cohorts 'catch up' somewhat with those of their older counterparts, a substantial gap remains at age 50. Early access to homeownership is also linked to the ownership of larger homes by middle age. Our study underscores the long-term consequences of housing market conditions on homeownership trajectories.