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2065107
Executive functions and associated brain volumetry in children with persistent stunting and catch-up growth
Abstract Early childhood stunting can result in sub-optimal executive functions (EF), affecting academic achievements and economic potential in later life. This study hypothesized that children always stunted (AS) at ages 2, 5 and 9 years had lower EF than those who were never stunted (NS). A birth-cohort in Vellore, India was followed up with periodic anthropometric and development/cognitive measures over 2, 5 and 9 years of age. Based on stunting status at these time points, children were classified as NS, stunted at 2 years and caught up by 5 years (S2N5), stunted at 2 and 5 years but caught up later (S5N9), and AS. At 9th year, children underwent neuroimaging using 3T MRI scanner and EF assessment using FAS phonemic fluency test, colour cancellation test and colour trials tests (CTT). From the original birth-cohort of 251, 205 children were reviewed at 9 years. FAS phonemic fluency test showed NS group had significantly higher test scores compared to AS (11.52 vs. 7.4, p = 0.02). In CTT, a significant difference in near misses score was observed between NS and AS groups (0.12 vs. 0.38, p = 0.03). Upon evaluating unimodal brain association areas, volumes of right occipital fusiform gyrus (9991 mm3 vs. 9313 mm3; p = 0.04; η2 = 0.11), and left lateral occipital cortex (13458 mm3 vs. 12559 mm3; p = 0.03; η2 = 0.07) were significantly higher among NS compared to AS group. Considering higher order association areas, only left pars triangularis was found to be significantly reduced among AS children compared to NS group (4284 mm3 vs. 3291 mm3; p = 0.01; η2 = 0.07). Similarly, there were also significance visible in the basal ganglia regions and the cerebellum. Current study demonstrated EF dysfunction in verbal fluency and inhibitory control in a dose response fashion in groups AS-to-NS with corresponding EF-related brain volumetric changes, highlighting the need for focused nutritional and nurturing approaches in early childhood for gain in human capital.
Impact of climate change on global catches of marine fisheries from 1971 to 2020
Marine fisheries catches have significant economic, social, and cultural importance for coastal communities and nations worldwide. In addition to overfishing and predation, oceanic conditions linked to climate variability profoundly affect catches of oceanic fish species. Based on the fishery data from the Food and Agriculture Organization (FAO) of the United Nations and multiple physical and biogeochemical datasets, we examined the correlation between major modes of climate variability at high and low frequency and multiple key fish species in five major fishing grounds worldwide. The results reveal that over 80% of selected key fish species have declined over the past five decades, with more than 50% transitioning from an increasing to a decreasing trend in the 1990s. Additionally, over 80% of fish species directly correlate with low-frequency climate indices, including Pacific Decadal Oscillation (PDO), Atlantic Multi-decadal Oscillation (AMO) and tropical southern Atlantic (TSA). However, less than 40% of fish species exhibit a direct association with high-frequency climate indices of El Niño Southern Oscillation (ENSO), North Atlantic Ocean (NAO), and Atlantic Niño (ATL3). Synthetic analysis on the Sea Surface Temperature (SST), Mixed Layer Depth (MLD) and chlorophyll a revealed that shifts in the low-frequency climate can directly affect the habitats of numerous fish species, and subsequently influence their fishing yields. Specially, negative SST anomalies and positive chlorophyll-a anomalies were observed during a positive phase of PDO in the central and western Pacific regions, resulting in an increased catch values of Alaska pollock, Pacific sardine, and Chilean jack mackerel. Similar changes occur in positive and negative phases of other low frequency indices. Our research offered a comprehensive perspective on oceanic fish catch responses to climate change, serving as a guide for formulating effective management strategies for marine fish resources.