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To listen to this broadcast, click here: http://www.npr.org/templates/transcript/transcript.php?storyId=nx-s1-5597865 BYLINE: MEL BRIDGES HOST: SCOTT DETROW SCOTT DETROW: Louisiana State Police have come under scrutiny for charging a former college football star […]

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Because plants are immobile, they have developed intricate mechanisms to sense and absorb nutrients, adjusting their growth and development accordingly. Sulfur is an essential macroelement, but our understanding of its metabolism and homeostasis is limited. LSU (RESPONSE TO LOW SULFUR) proteins are plant-specific proteins with unknown molecular functions and were first identified during transcriptomic studies on sulfur deficiency in Arabidopsis. These proteins are crucial hubs that integrate environmental signals and are involved in the response to various stressors. Herein, we report the direct involvement of LSU proteins in primary sulfur metabolism. Our findings revealed that the quadruple lsu mutant, q-lsu-KO, which was grown under nonlimiting sulfate conditions, exhibited a molecular response resembling that of sulfur-deficient wild-type plants. This led us to explore the interactions of LSU proteins with sulfate reduction pathway enzymes. We found that all LSU proteins interact with ATPS1 and ATPS3 isoforms of ATP sulfurylase, all three isoforms of adenosine 5 phosphosulfate reductase (APR), and sulfite reductase (SiR). Additionally, in vitro assays revealed that LSU1 enhances the enzymatic activity of SiR. These results highlight the supportive role of LSU proteins in the sulfate reduction pathway.

Science gateways are identified as an effective way to publish and distribute software for research communities without the burden of learning HPC (High Performance Computer) systems. In the past, researchers were expected to have in-depth knowledge about using HPC systems for computations along with their respective science field in order to do effective research. Science gateways eliminate the need to learn HPC systems and allows the research communities to focus more on their science and let the gateway handle communicating with HPCs. In this poster we are presenting the science gateway project of CSBG (Computational System Biology Group - www.brylinski.org) of Department of Biological Sciences with Center for Computation & Technology at LSU (Louisiana State University). The gateway project was initiated in order to provide CSBG software tools as a service through a science gateway.