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BackgroundWorkday sleep deprivation has become normalized in contemporary society. While previous research suggested that weekend catch-up sleep (WCS) could reduce the risk of depression, there is currently limited evidence supporting the role of WCS in reducing the development of specific depressive symptoms. Therefore, the objective of this study was to investigate the relationship between WCS and specific depressive symptoms among American.MethodsA total of 7,695 participants were recruited from the 2017–2020 NHANES. Concurrently, an external validation set comprising 180 independent clinical participants from Xijing Hospital was collected. The presence of depressive symptoms was determined through analysis of the PHQ-9 questionnaire, with each item representing one distinct type of depressive symptom. Multivariate logistic regression and generalized additive models were used to determine the correlation between WCS sleep and specific depressive symptoms. Subgroup analysis was used to reveal differences between WCS and specific depressive symptoms in specific populations.ResultsThe findings of the multiple logistic regression analysis indicated that WCS associated with a wide range of specific depressive symptoms, particularly suicidal ideation, with OR = 0.53 (95% CI: 0.33–0.85) in the NHANES group and OR = 0.12 (95% CI: 0.04–0.41) in the clinical sample. Following adjustment for all covariates, non-linear associations of WCS with sleep disturbance and psychomotor disturbance in both samples (NHANES/Xijing Hospital). Furthermore, the results of subgroup analyses indicated that specific subgroups of the vast majority of depressive symptoms were correlated with WCS.ConclusionsThe results of this study confirm that WCS inversely related to specific depressive symptoms, particularly among individuals under 35 with suicidal ideation.

The use of light in pots has been shown to increase snow crab catch rates in eastern Canada and the Barents Sea, where better fishing efficiency could result in less fuel consumption, and financial and ecological benefits. However, some light characteristics necessary for maximizing efficiency have yet to be researched. The purpose of this study was to determine if there is a change in catch per unit effort (CPUE; number of snow crab per pot) and size selectivity of snow crab with varying light intensity. Three types of experimental luminescent-netting pots were used, each type with a different level of light intensity via the amount of phosphorescent strands woven into the pot netting, (either 2-, 4-, or 6-strands) and were compared to the traditional pot used in the fishery. There were mixed results among treatments, with the 2-strand pot catching fewer snow crab

Several evidence gaps exist regarding the use of long-acting polyethylene glycol recombinant human growth hormone (PEG-rhGH) in children with idiopathic short stature (ISS), particularly studies conducted in real-world settings, with long-term follow-up, involving varied dosing regimens, and in comparison with daily rhGH. The study aimed to evaluate the effectiveness, safety, and adherence of once-weekly PEG-rhGH for catch-up growth in children with prepubertal ISS compared to daily rhGH. A real-world retrospective cohort study was conducted in prepubertal children with ISS in China. Children who voluntarily received once-weekly PEG-rhGH or daily rhGH were included and were followed up for 2 years. Ninety-five children were included, 47 received PEG-rhGH 0.2–0.3 mg/kg weekly and 48 received daily rhGH. Outcome measures included effectiveness in catch-up growth, adverse events, and treatment adherence. Height velocity increased significantly in both groups during rhGH therapy. In children who received PEG-rhGH treatment, height velocity was 10.59 ± 1.37 cm/year and 8.75 ± 0.86 cm/year in the first and second year, respectively, which were significantly more than those who received daily rhGH (9.80 ± 1.05 cm/year, P = 0.002, and 8.03 ± 0.89 cm/year, P 

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The irresistible O'Donnell brothers return in a charming novel from the bestselling author of Off the Hook (“The perfect balance of sweet, sexy, and wonderfully romantic.”—Lauren Layne). Hope Seaver is an up-and-coming TV producer tackling the hardest gig of her career: a reality show set at the Buoys, a scenic fishing destination owned by three handsome, stubborn brothers. Liam and Finn O'Donnell are willing to tolerate her crew for the sake of the business, but Ronan would rather chew off a limb than open up on camera. Somehow Hope has to convince him of her good intentions—and stop herself from swooning every time Ronan walks into the frame. Ronan knows that he's the reason his brothers gave up their old lives to run the Buoys, and he needs to make it worth their while. So if this out-of-towner with the kind eyes and dazzling smile wants to give them the free publicity they desperately need, Ronan can't say no. He just won't let himself get burned again by a double-dealing woman. But what if Hope's good-girl routine isn't an act? When Ronan lets his guard down long enough to catch a glimpse of the real Hope, he likes what he sees—enough to give love another shot. Look for all of Laura Drewry's heartwarming Fishing for Trouble romances: OFF THE HOOK | LURED IN | CATCH AND RELEASE “A must-read for fans of second-chance love stories, Off the Hook is the perfect balance of sweet, sexy, and wonderfully romantic.”—USA Today bestselling author Lauren Layne “Drewry struck the right balance between the heavier, more serious or emotional parts with humor and heat.”—Harlequin Junkie, on Off the HookPraise Catch and Release“A slow-burn romance... Laura Drewry brought tension, anticipation, angst, sexy, heartwarming, and romance together in a book I didn't want to put down.”—Harlequin Junkie “If you enjoy heavily family oriented romances with just the right amount of angst, a touch of sexy and a true romantic feel, this is a book, and an author, that you should definitely pick up.”—Fiction Fangirls “Unfailingly engaging, clever, highly amusing, insightful, and emotively heart-squeezing.”—Books and Bindings “Another page-turner. I couldn't put it down but I didn't want it to be over.”—Roberta's Dream World “Laura Drewry writes in a way that makes you feel that you are a part of the story and her descriptions of the setting makes me want to visit the Buoys for a fishing vacation.... The perfect blend of family dynamics, romance, emotional and fun moments.”—Comfy Chair Books Includes an excerpt from another Loveswept title.

Recreational angling for novel marine species and related tourism development can be important in a Blue Economy. The milkfish (Chanos chanos) is growing in popularity as a target of fly fishing‐based catch‐and‐release (C&R) recreational fisheries, largely because of their challenge to catch and powerful swimming abilities, resulting in fight times that can exceed 1 h. Anecdotal sentiments by anglers claim that milkfish can fight for long periods of time because they do not accumulate blood lactate. To test this hypothesis, we measured blood lactate and blood glucose for 21 milkfish caught by fly fishing in the remote Alphonse Group of islands, Republic of Seychelles. Fight times ranged 5–78.3 min. Blood lactate and blood glucose concentrations increased with fight times that did not exceed 60 min. Total length of milkfish was not correlated to blood lactate or blood glucose concentrations. Ours is the first study on C&R of milkfish that debunks the anecdote that milkfish can fight for long periods of time because they do not accumulate blood lactate. Our study also revealed that milkfish may begin to physiologically recover after fight times longer than 60 min. In the context of C&R, our study indicates that anglers should limit fight times to 20–30 min when possible to reduce angling‐induced physiological stress and other potential impacts (e.g., depredation) on milkfish in recreational fisheries. [ABSTRACT FROM AUTHOR]

Gillnets are the most commonly used fishing gear targeting black rockfish (Sebastes schlegeli) and fat greenling (Hexagrammos otakii) in the artificial reef area in coastal China. However, a minimum mesh size (MMS) has not yet been established for this fishery, which is unfavorable for sustainable development and effective management of fishery resources. We compared size selectivity and catch efficiency of gillnets of four commonly used mesh size (stretched mesh size; 40, 50, 60, and 70‐mm) in a typical artificial reef area in the Yellow Sea, China. Increasing the mesh size improved size selectivity of gillnets for black rockfish and fat greenling by reducing the proportion of undersized individuals. Further, changes in mesh size affected catch efficiency of target‐sized individuals. To protect juveniles, while maintaining catch efficiency for target‐sized fish, we recommend 60‐mm as the MMS for this fishery. Our study will contribute to the development of MMS regulations in reef fisheries management in China. [ABSTRACT FROM AUTHOR]

Izumo1:Juno-mediated adhesion between sperm and egg cells is essential for mammalian sexual reproduction. However, conventional biophysical and structural approaches have provided only limited functional insights. Using atomic force microscopy-based single-molecule force spectroscopy and all-atom steered molecular dynamic simulations, we explore the role of mechanical forces in regulating the human Izumo1:Juno complex. Our findings reveal a multi-state catch bond capable of withstanding forces up to 600 pN– mechanostability rarely observed among eukaryotic protein complexes. We find that this enhanced mechanostability is impaired in the infertility-associated mutant, JunoH177Q. Detailed steered molecular dynamics simulations show how force-dependent structural reorganization of the Izumo1:Juno complex engages previously undiscovered binding conformations to achieve this state of high mechanostability. Overall, this study significantly enhances our understanding of the mechanical underpinnings that regulate human fertilization.Sperm–egg adhesion is crucial for mammalian reproduction. Here, authors report the human Izumo1:Juno complex, a key regulator of sperm-egg adhesion, forms an unusually strong bond through a secondary binding site, which is impaired in an infertility-associated Juno mutant.

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This study investigates the impact of the COVID-19 pandemic on pupils and the potential value of outdoor learning (OL) as a strategy to overcome some of the challenges educators face in helping their pupils get 'back on track'. Interviews with nine primary school staff in the South West of England explored the impact of the pandemic on pupil wellbeing, academic attainment, friendships/social skills, and behaviour. We report on the effectiveness of OL in this context. Findings indicate that OL is being deployed as a useful post-pandemic pedagogical tool. Barriers to consistently implementing OL as a teaching strategy are discussed.

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