Test out our new Bento Search

Mucosal-mediated immune deficiency is associated with immune evasion and poor clinical outcomes in acute myeloid leukemia (AML). Here, we describe the elicitation of mucosal and systemic immune response by oral delivery of MDP-modified PEG-lipid (MDP-PEG-DSPE) and polylactic acid–polyhistidine (PLA–PHis) copolymer constructed nanosystem (mPOD) into Peyer’s patches. To protect against gastrointestinal degradation, enteric-soluble capsules are utilized for encapsulating mPOD to promote penetration across intestinal mucus and engender robust Peyer’s patch targeting initiated by MDP-PEG-DSPE. Compared with intravenous and intramuscular administration, the oral delivery of MDP-PEG-DSPE and 5′-triphosphate-modified RNA (ppp-RNA) into gut-associated lymphoid tissues reinforces dendritic cell maturation and migration, amplifies mucosal immune response, and boosts the production of secretory immunoglobulin A via retinoic acid-inducible gene I/nucleotide-binding oligomerization domain 2 (RIG-I/NOD2) signaling activation. In the AML murine model, the provoked mucosal immunity positively regulates the systemic cytotoxic immune reactions, which, in turn, eradicate disseminated malignant leukemic cells and provide defense against leukemia attacks.

The Catch can now be found in Standing by the Wall, the collection of other novellas set in the world of the New York Times bestselling Slough House series.John Bachelor is the saddest kind of spy: not a joe in the field, not even a desk jockey, but a milkman—a part-time pension administrator whose main job is to check in on aging retired spies. Late in his career and having lost his wife, his house, and his savings after a series of unlucky choices, John's been living in a dead man's London apartment, hoping the bureaucracy isn't going to catch up with him and leave him homeless. But keeping a secret among spies is a fool's errand, and now John has made himself eminently blackmailable.

The notion of green industrial policy (GIP) has gained attention recently in order to conceptualize the relationship between the transition to green technologies and the development of domestic manufacturers of such technologies. In this paper, we contribute to advancing the literature on GIP by presenting a conceptual framework on GIP in the context of latecomer catch-up of domestic firms in developing countries. The framework combines insights from the development studies literature on industrial policies, policy mixes in sustainability transition studies and the literature on firm-level catch-up. We apply the framework to study how industrial policies and energy policies have interacted and influenced the initial entry and early-stage catch-up of domestic solar PV module manufacturers in Indonesia in the period 2008–2023. Empirically, we draw on semi-structured interviews with representatives of domestic solar PV module manufacturers, industry informants and relevant government agencies. Based on the conceptual framework, we identify the inhibiting and encouraging factors influencing firm-level catch-up trajectories within three distinctive phases. We find that, while the catch-up trajectory of domestic solar PV module manufacturers resembled a path toward coexistence during the first and second phases, the third phase involved an aborted catch-up trajectory. However, a new catch-up trajectory toward coexistence may be emerging in relation to the recent establishment of export-oriented solar PV module production. Conceptually, the paper contributes to advancing the literature on GIPs by adopting a firm-oriented perspective and by seeking closer integration with research in development studies on the catching-up of latecomer firms.

Introduction Short, late, and irregular sleep are associated with increased risk for depression, a leading cause of disability in adolescents and young adults. This study evaluates the hypothesis that weekend catch-up sleep (WCS) can reduce depressive symptoms in late adolescents and young adults.Methods Secondary analyses were conducted using a nationally-representative sample of 16–24-year-olds in the National Health and Nutrition Examination Survey (NHANES 2021–2023; N = 1087). Participants' reports of weekend and weekday bed- and wake-times were used to calculate WCS (>0 h or ≤ 0 h). Depression was operationalized as participant report of feeling “sad or depressed” daily. Analyses included the causal inference technique of inverse probability weighting with regression adjustment. Survey design variables were used to calculate propensity scores and inverse probability weights and then incorporated into the final multivariate logistic regression model which evaluated the relationship between WCS and daily depressive symptoms, covarying for weekday sleep duration and midpoint, body mass index, age, sex, and race/ethnicity.Results Late adolescents and young adults with WCS had 41 % lower odds of daily depressive symptoms compared to those without WCS, with similar results from causal inference and traditional multivariate regression models. Healthy weekday sleep duration at an optimal time each had twice the benefit for depressive symptoms.Conclusion WCS may reduce the incidence of daily depressive symptoms in late adolescents and young adults. WCS can be a healthy sleep habit, but additional research is needed to parse the relative benefits of WCS versus consistent and optimized weekday-weekend sleep duration and timing.

Objective This study investigated the association between weekend catch-up sleep (WCS) and systemic inflammation, as indicated by serum white blood cell (WBC) counts.Methods A cross-sectional study of 22,143 participants from the Korea National Health and Nutrition Examination Survey (2016–2018, and 2021) categorized into no-WCS (

Thirty-something Nash'Watch'Dixon watches patients for a living. He works at Kimerman Hall, a mental illness facility, and makes sure his patients don't harm themselves. In his spare time Watch can't help himself and watches his hot and steamy neighbor across the street, Liam Caughtler, who has caught Watch's eye. Watch knows Liam, host of the hit reality show Catch and Release, likes men. A bunch of men. Maybe too many men. If only Liam would be more than his friend. He often wonders if Liam will stop catching and releasing and finally settle down with one man. Can this one man be him? Who knows? As summer turns steamy and hot, Watch learns a mind-blowing secret about Liam. And after he confronts Liam about it, the two just might turn out be summertime lovers.